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Immunotherapy in Allergic and Mixed Rhinitis
Tolly Epstein1, David I Bernstein1
1Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Immunology and Allergy Clinics of North America
|November 15, 2025
Summary
Allergen immunotherapy, including subcutaneous (SCIT) and sublingual (SLIT) methods, effectively treats allergic rhinitis. SLIT offers a superior safety profile, making it a preferred option for managing allergy severity.
Area of Science:
- Allergy and Immunology
- Immunotherapy Research
- Respiratory Medicine
Background:
- Allergic rhinitis significantly impacts quality of life.
- Allergen immunotherapy is the sole disease-modifying treatment.
- Current options include Subcutaneous Immunotherapy (SCIT) and Sublingual Immunotherapy (SLIT).
Purpose of the Study:
- To review the efficacy of individual allergens in immunotherapy.
- To compare the relative efficacy of SLIT and SCIT.
- To assess the safety profiles of SLIT and SCIT.
Main Methods:
- Literature review of existing studies.
- Analysis of clinical trial data.
- Comparative assessment of treatment outcomes and adverse events.
Main Results:
- Both SCIT and SLIT demonstrate significant efficacy in treating allergic rhinitis.
- SLIT is associated with a better safety profile and fewer systemic reactions.
- Evidence supports the effectiveness of specific allergens within immunotherapy protocols.
Conclusions:
- Allergen immunotherapy is a cornerstone treatment for allergic rhinitis.
- SLIT presents a favorable safety and efficacy balance.
- Further research can refine allergen selection and delivery methods for optimal patient outcomes.
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