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Gentamicin-induced anaphylaxis.

M Connolly1, J McAdoo, J F Bourke

  • 1Dermatology Department, Adelaide & Meath Hospital Dublin Incorporating The National Children's Hospital, Tallaght, Dublin 24, Ireland. maureen.connolly@amnch.ie

Irish Journal of Medical Science
|August 29, 2007
PubMed
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Anaphylaxis to gentamicin, a rare immediate hypersensitivity reaction, occurred in a patient presenting with severe symptoms like urticaria and hypotension. Diagnostic tests confirmed gentamicin allergy, highlighting the importance of considering this severe reaction.

Area of Science:

  • Clinical immunology
  • Pharmacovigilance

Background:

  • Gentamicin is a frequent cause of allergic contact dermatitis.
  • Immediate (type 1) hypersensitivity reactions to gentamicin are uncommon.

Observation:

  • A 69-year-old male experienced anaphylaxis after intravenous gentamicin administration.
  • Symptoms included urticaria, hypotension, and loss of consciousness within minutes.

Findings:

  • The patient recovered fully after resuscitation.
  • Both prick testing and patch testing confirmed a positive reaction to gentamicin.

Implications:

  • This case underscores the potential for severe anaphylaxis to gentamicin, despite its rarity.
  • Highlights the need for vigilance in diagnosing and managing immediate hypersensitivity to gentamicin.

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