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Updated: Jul 12, 2026
04:17
Determining the Serum Stability of Human Adenosine Deaminase 1 Enzyme
Published on: September 27, 2024
Changes in serum adenosine deaminase activity during normal pregnancy
Soo Jin Lee1, Han Sung Hwang, Bit Na Rae Kim
1Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Journal of Korean Medical Science
|August 31, 2007
Summary
Serum adenosine deaminase (ADA) activity, crucial for immune cell development, was studied in 202 pregnant women. ADA levels peaked significantly in the third trimester, offering insights for managing immune-related pregnancy complications.
Area of Science:
- Immunology
- Biochemistry
- Obstetrics
Background:
- Adenosine deaminase (ADA) is vital for lymphoid cell differentiation and immune system monitoring.
- Understanding ADA activity during pregnancy is crucial for managing immune-related conditions.
Purpose of the Study:
- To investigate serum ADA activity changes across normal pregnancy.
- To establish reference values for serum ADA during gestation.
Main Methods:
- Serum ADA catalytic activity was measured in 202 normal pregnant women using a commercial kit.
- Participants were categorized into four groups based on gestational age (5-9, 15-20, 24-30, and 30-39 weeks).
Main Results:
- Serum ADA activity showed a significant increase in the 24-30 weeks gestational group (37.9 +/- 19.9 IU/L) compared to other trimesters.
- No significant correlation was found between gestational age and serum ADA activity overall.
- Maternal age, gestational age at delivery, delivery mode, and birth weight did not correlate with ADA activity.
Conclusions:
- Serum ADA activity exhibits a notable elevation in mid-to-late pregnancy (24-30 weeks).
- These findings provide essential reference values for serum ADA in normal pregnancy.
- This data can aid clinical decisions in pregnancies with altered cellular immunity.
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