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Drug-induced pancreatitis: a practical review
Rohtashav Dhir1, Daniel K Brown, Kevin W Olden
1Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Drug-induced pancreatitis is a rare condition with limited literature. This review covers its features, causes, mechanisms, and management strategies for better diagnosis and treatment.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Drug-induced pancreatitis is an uncommon but significant cause of acute pancreatitis.
- Existing literature is predominantly based on case reports, limiting comprehensive understanding.
Purpose of the Study:
- To review the clinical and epidemiological characteristics of drug-induced pancreatitis.
- To identify commonly associated drugs and conditions linked to pancreatitis.
- To elucidate pathogenic mechanisms and propose a diagnostic and management approach.
Main Methods:
- Systematic literature review of drug-induced pancreatitis.
- Analysis of clinical presentations, epidemiological data, and associated factors.
- Discussion of proposed pathogenetic mechanisms.
Main Results:
- Identified numerous drugs implicated in acute pancreatitis etiology.
- Highlighted challenges in accurate diagnosis and management.
- Detailed common drug associations and potential pathogenic pathways.
Conclusions:
- Drug-induced pancreatitis requires a systematic approach for diagnosis and management.
- Further research is needed to expand the limited literature on this condition.
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