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Vitamin D suppression of spleen colony formation in radiation chimeras
N Nuwayri-Salti1, J Abdel-Halim, Z Salem
1Department of Human Morphology, American University of Beirut, Faculty of Medicine, New York, N.Y.
Pharmacology
|January 1, 1991
Abstract:
The effect of vitamin D on spleen colonies in murine bone marrow chimeras was investigated using a single suprapharmacologic dose of vitamin D. The results revealed that vitamin D even without producing hypercalcemia, reduced to a significant degree the number of spleen colonies obtained. This finding is thought to be due to either a direct effect of the vitamin on the capacity of stem cells to multiply or an effect on the number of stem cells that lodge in the spleen.