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Related Concept Videos

Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Updated: Jul 12, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

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Published on: June 15, 2011

When do anomalies begin?

A Lightman, O Gingerich

    Science (New York, N.Y.)
    |February 7, 1992
    PubMed
    Summary

    Scientific anomalies are often recognized only after new theories explain them, revealing a "retrorecognition" phenomenon. This highlights key aspects of scientific discovery and human psychology.

    Area of Science:

    • Philosophy of Science
    • Cognitive Psychology
    • History of Science

    Background:

    • Scientific anomalies challenge existing theories.
    • Anomalies can drive scientific progress and paradigm shifts.

    Purpose of the Study:

    • To explore the phenomenon of
    • retrorecognition
    • in scientific discovery.
    • To analyze how anomalies are identified and integrated into new conceptual frameworks.

    Main Methods:

    • Conceptual analysis of scientific discovery processes.
    • Examination of historical scientific case studies.
    • Psychological analysis of cognitive biases in scientific interpretation.

    Main Results:

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    • Anomalies are often recognized retrospectively, once explained by a new theory.
    • The identification of anomalies is influenced by the prevailing theoretical framework.
    • This retrorecognition highlights the interplay between observation, theory, and psychological factors.

    Conclusions:

    • The recognition of scientific anomalies is not always immediate but can be retrospective.
    • The process of scientific discovery involves psychological elements influencing the interpretation of data.
    • Understanding retrorecognition offers insights into theory change and cognitive processes in science.