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Neuroblastoma-like schwannoma: Case report with histopathologic correlation
Diana Caicedo1, Natalia Rodríguez2, Rafael Vélez3
1Sección Dermatopatología, Universidad CES, Medellín, Colombia.
Biomedica : Revista Del Instituto Nacional De Salud
|June 30, 2026
Summary
Rosette-forming neuroblastomatous schwannoma is a rare variant of schwannoma presenting diagnostic challenges. This case highlights its identification through histopathology and immunohistochemistry in a chest wall tumor.
Area of Science:
- Oncology
- Pathology
- Surgical Case Reports
Background:
- Schwannomas are nerve sheath tumors, with rare variants posing diagnostic difficulties.
- Rosette-forming neuroblastomatous schwannoma is an uncommon subtype with limited literature.
- Accurate diagnosis is crucial for appropriate patient management.
Purpose of the Study:
- To present a case of rosette-forming neuroblastomatous schwannoma.
- To discuss diagnostic challenges and differential diagnoses.
- To review relevant literature emphasizing immunohistochemistry.
Main Methods:
- Case presentation of a 40-year-old female patient.
- Histopathological and immunophenotypic analysis of the tumor.
- Literature review focusing on differential diagnosis and immunohistochemical markers.
Main Results:
- Diagnosis of rosette-forming neuroblastomatous schwannoma confirmed.
- The tumor presented as a progressive, painful nodule on the anterior chest wall.
- Immunohistochemistry played a key role in differentiating from other neoplasms.
Conclusions:
- Rosette-forming neuroblastomatous schwannoma is a rare entity requiring careful diagnostic evaluation.
- Histopathology and immunohistochemistry are essential for accurate diagnosis.
- Further case reports are needed to better understand this variant.
