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[Mitral valve prolapse associated with Basedow's disease and active hyperthyroidism. Preliminary report].

P Piraino1, M L Zura, O Loureiro

  • 1Servicio de Medicina Hospital San José.

Revista Medica De Chile
|June 1, 1990
PubMed
Summary

Graves disease patients with hyperthyroidism showed a higher incidence of mitral valve prolapse (MVP). Further research is needed to confirm this link between hyperthyroidism and MVP.

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Area of Science:

  • Cardiology
  • Endocrinology

Background:

  • Graves disease is an autoimmune disorder causing hyperthyroidism.
  • Hyperthyroidism can affect multiple organ systems, including the cardiovascular system.
  • Mitral valve prolapse (MVP) is a common cardiac condition.

Purpose of the Study:

  • To investigate the prevalence of mitral valve prolapse (MVP) in patients with Graves disease and active hyperthyroidism.
  • To compare MVP incidence in hyperthyroid patients versus a healthy control group.

Main Methods:

  • Two-dimensional echocardiograms were used to assess for MVP.
  • 21 patients with Graves disease and active hyperthyroidism were included.
  • 22 healthy subjects served as the control group.

Main Results:

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  • The incidence of MVP was 24% in hyperthyroid patients, compared to 5% in the control group.
  • No significant differences in age, T3, or T4 levels were observed between hyperthyroid patients with and without MVP.
  • Hyperthyroid patients with MVP had a longer clinical course.

Conclusions:

  • A higher incidence of MVP may be associated with Graves disease and active hyperthyroidism.
  • Larger studies are warranted to establish a definitive link between hyperthyroidism and MVP.
  • Echocardiographic screening for MVP may be considered in patients with hyperthyroidism.