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Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Variance01:15

Variance

The deviations show how spread out the data are about the mean. A positive deviation occurs when the data value exceeds the mean, whereas a negative deviation occurs when the data value is less than the mean. If the deviations are added, the sum is always zero. So one cannot simply add the deviations to get the data spread. By squaring the deviations, the numbers are made positive; thus, their sum will also be positive.The standard deviation measures the spread in the same units as the data.

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Related Experiment Video

Updated: Jul 1, 2026

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Erratum

    Science (New York, N.Y.)
    |August 7, 1987
    PubMed
    Summary

    Corrections were issued for a report on T-even phages. The study found the nrdB intron occurs variably, suggesting mobility within these phage genomes.

    Area of Science:

    • Molecular Biology
    • Virology
    • Genetics

    Background:

    • The report "Variable occurrence of the nrdB intron in the T-even phages suggests intron mobility" by Pedersen-Lane and Belfort contained printing errors.
    • Accurate scientific reporting is crucial for disseminating research findings in molecular biology and virology.

    Purpose of the Study:

    • To provide corrected sentences from the original report.
    • To ensure accurate understanding of intron homology and experimental methods in T-even phages.

    Main Methods:

    • Correction of specific sentences within the published report.
    • Reference to hybridization and dideoxy primer-extension analysis of pre-messenger RNA (pre-mRNA).
    • Clarification of oligonucleotide probe descriptions used in figure legends.

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    Last Updated: Jul 1, 2026

    Molecular Evolution of the Tre Recombinase
    12:02

    Molecular Evolution of the Tre Recombinase

    Published on: May 29, 2008

    The Lambda Select cII Mutation Detection System
    07:08

    The Lambda Select cII Mutation Detection System

    Published on: April 26, 2018

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
    05:46

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

    Published on: September 20, 2024

    Main Results:

    • The td intron is homologous throughout the T-even phages.
    • Experimental validation involved hybridization and primer-extension analysis.
    • Oligonucleotide probes were clearly defined for experimental reproducibility.

    Conclusions:

    • The corrected information clarifies the homology of the td intron in T-even phages.
    • Accurate methodology descriptions are essential for validating findings on intron mobility.