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Updated: Jul 12, 2026

Non-invasive Imaging of the Innate Immune Response in a Zebrafish Larval Model of Streptococcus iniae Infection
Published on: April 21, 2015
Invasive infection with Streptococcus iniae in Taiwan
Jun-Ren Sun1, Juh-Cheng Yan2, Ching-Ying Yeh1
1Division of Clinical Pathology, Department of Internal Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC.
Streptococcus iniae, a fish pathogen, can rarely infect humans. This case report details a successful ampicillin treatment for an invasive infection in a woman with diabetes and liver cirrhosis.
Area of Science:
- Microbiology
- Infectious Diseases
- Human Health
Background:
- Streptococcus iniae is a known pathogen in fish populations.
- Human infections with S. iniae are uncommon, posing diagnostic challenges.
- Comorbidities like diabetes and liver disease may increase susceptibility.
Observation:
- A 51-year-old woman with diabetes mellitus and liver cirrhosis presented with an invasive infection.
- The causative agent was identified as Streptococcus iniae using 16S rDNA sequencing.
- The patient had no history of fish exposure, highlighting potential transmission routes.
Findings:
- The patient's infection was confirmed as invasive Streptococcus iniae.
- 16S rDNA sequencing provided accurate identification of the bacterial species.
- Prompt diagnosis and treatment led to a full recovery.
Implications:
- This case underscores the importance of considering S. iniae in human infections, especially in immunocompromised individuals.
- Early identification and appropriate antibiotic therapy are crucial for favorable outcomes.
- Further research is needed to understand the epidemiology and transmission of S. iniae in humans.
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