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Updated: Jul 12, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke
Background And Purpose:
Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke.
Methods:
We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy.
Results:
Voxel-based analysis showed excellent correlation between apparent diffusion coefficient values, lactate, and N-acetyl-aspartate levels at all time points. Lactate decreased during NBO and increased post-NBO. N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients.
Conclusions:
These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain.
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