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Updated: Jul 12, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Recurrent hemorrhagic stroke in children: a population-based cohort study
Heather J Fullerton1, Yvonne W Wu, Stephen Sidney
1Department of Neurology, University of California, San Francisco, Box 0114, San Francisco, CA 94143-0114, USA. fullertonh@neuropeds.ucsf.edu
Stroke
|September 1, 2007
Summary
Recurrent hemorrhagic strokes (HS) affect 1 in 10 children within 5 years. Children with structural lesions face a prolonged, high risk of recurrent HS, unlike those with idiopathic or medically-induced HS.
Area of Science:
- Pediatric Neurology
- Neuroscience
- Public Health
Background:
- Hemorrhagic strokes (HS) constitute 50% of pediatric strokes.
- Rates and predictors of recurrent HS in children remain understudied.
Purpose of the Study:
- To determine the rates and identify predictors of recurrent HS in a pediatric population.
- To analyze recurrence patterns based on the etiology of initial HS.
Main Methods:
- Retrospective cohort study of 2.3 million children (<20 years) from 1993-2004.
- Kaplan-Meier survival analysis to calculate cumulative recurrence rates (CRR).
- Bivariate comparisons using log rank tests to assess differences between etiological groups.
Main Results:
- 116 children with atraumatic HS were followed; 11 experienced recurrence within 5 years (10% CRR).
- Recurrences predominantly occurred within 6 months (64%).
- Children with structural lesions (vascular malformations, tumors) had a 5-year CRR of 13%, significantly higher than those with idiopathic HS (0% recurrence).
Conclusions:
- Approximately 10% of pediatric HS cases recur within 5 years.
- Structural lesions are associated with a high and prolonged risk of recurrence.
- Idiopathic HS rarely recur, while medically-induced HS tend to recur acutely.
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