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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
New advances in acute pancreatitis
Matthew J DiMagno1, Eugene P DiMagno
1University of Michigan Medical School, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ann Arbor, Michigan, USA. mdimagno@umich.edu
Current Opinion in Gastroenterology
|September 1, 2007
Summary
Recent advances in acute pancreatitis highlight new insights into alcoholic pancreatitis and recurrent cases. Persistent organ failure predicts mortality, while enteral feeding is recommended for severe cases, but prophylactic antibiotics lack data.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Acute pancreatitis remains a significant clinical challenge with evolving understanding of its epidemiology and etiology.
- Recent research focuses on refining risk stratification and management strategies for acute pancreatitis.
Purpose of the Study:
- To review key advancements in the clinical understanding of acute pancreatitis over the past year.
- To highlight new observations and insights into established and emerging concepts in acute pancreatitis management.
Main Methods:
- Systematic review of recent literature on acute pancreatitis.
- Focus on clinical studies providing new data on diagnosis, etiology, and treatment.
Main Results:
- Case fatality rates for acute pancreatitis have stabilized.
- Carbohydrate-deficient transferrin predicts alcoholic acute pancreatitis; genetic mutations in cystic fibrosis transmembrane conductance regulator are frequent in recurrent cases.
- Persistent organ failure, not necrosis extent, predicts mortality; enteral feeding is recommended for severe acute pancreatitis, while prophylactic antibiotics lack evidence.
Conclusions:
- Recent studies have further characterized the epidemiology, etiology, and risk stratification of acute pancreatitis.
- Key evolving areas include chemoprevention of post-ERCP pancreatitis and nutritional support in severe cases.
- Further research is needed to translate novel therapies into clinical practice.
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