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Updated: Jul 12, 2026
08:46
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Fertility preservation in gynecologic cancers
1Department of Obstetrics and Gynecology, Joan and Sanford I. Weill Medical College of Cornell University, New York, NY 10021, USA. koktay@fertilitypreservation.org
Current Opinion in Oncology
|September 1, 2007
Summary
Young women undergoing gynecologic cancer treatment have multiple fertility preservation options. Established methods like embryo and oocyte cryopreservation offer high success rates, with newer techniques still under investigation.
Area of Science:
- Reproductive Medicine
- Oncology
- Gynecology
Background:
- Young women treated for gynecologic cancer face risks of premature ovarian failure and infertility.
- Fertility preservation is a critical concern for these patients.
Purpose of the Study:
- To review current fertility preservation options for young women at risk of infertility due to gynecologic cancer treatment.
- To inform clinical practice and patient counseling.
Main Methods:
- Literature review of established and experimental fertility preservation techniques.
- Analysis of success rates and applicability of different methods.
Main Results:
- Embryo cryopreservation is the most established method with success rates approaching fresh embryo transfers.
- Oocyte cryopreservation success rates are improving and nearing those of embryo freezing.
- Aromatase inhibitors can minimize estrogen exposure during stimulation for estrogen-sensitive cancers.
- Ovarian-tissue cryopreservation, in-vitro maturation, and xenografting are less established or experimental.
Conclusions:
- Multiple fertility preservation techniques are available, with others in development.
- All young individuals with gynecologic cancer should receive counseling on fertility preservation options, aligning with ASCO guidelines.
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