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Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Group Design02:01

Group Design

The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between the two are due to...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...

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Related Experiment Video

Updated: Jul 12, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
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Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Randomised controlled trials in overweight children: practicalities and realities.

Janet M Warren1, Rebecca K Golley, Clare E Collins

  • 1University of Newcastle, Schools of Health Sciences and Education, Callaghan Campus, Newcastle, New South Wales, Australia. j.warren@uq.edu.au

International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity
|September 1, 2007
PubMed
Summary

Conducting high-quality randomised controlled trials (RCTs) with overweight and obese children requires careful planning. Strategies for recruitment, retention, and family engagement are crucial for successful interventions.

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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Area of Science:

  • Pediatric obesity research
  • Clinical trial methodology

Background:

  • Three Australian interventions involving overweight/obese children provided practical insights.
  • Key challenges include study design, ethical approval, outcome measures, recruitment, family engagement, and data management.

Purpose of the Study:

  • To discuss practical aspects of conducting high-quality randomised controlled trials (RCTs) for pediatric obesity.
  • To offer suggestions for researchers based on real-world intervention experiences.

Main Methods:

  • Review of experiences from three Australian intervention studies.
  • Identification and discussion of practical issues in pediatric RCTs.

Main Results:

  • Multi-site trials enhance sample size and external validity despite higher costs.
  • Common challenges in recruitment, retention, and family collaboration were identified.

Conclusions:

  • Interventions for pediatric overweight/obesity are complex and require strategic approaches.
  • Developed strategies address common RCT challenges, particularly recruitment, retention, and family engagement.