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Updated: Jul 12, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Highly enantioselective carbonyl-ene reactions catalyzed by a hindered silyl-salen-cobalt complex
Gerri E Hutson1, Apurva H Dave, Viresh H Rawal
1Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Abstract:
We report here the enantioselective carbonyl-ene reactions of various 1,1-disubstituted and trisubstituted alkenes with ethyl glyoxylate. The reactions are catalyzed by a new Co-salen complex, in which bulky triisobutylsilyl (TIBS) substituents occupy the positions ortho to the phenolic oxygens. This complex catalyzes the reactions under nearly ideal conditions - at room temperature and using catalyst loadings as low as 0.1 mol % - and provides the chiral, homoallylic alcohol products in excellent yields, enantioselectivities, and diastereoselectivities.
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