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Updated: Jul 12, 2026
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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Rhinal cortex asymmetries in patients with mesial temporal sclerosis
Catherine E Meade1, Stephen C Bowden, Greg Whelan
1St. Vincent's Hospital Melbourne, Clinical Neurosciences, Victoria Pde, Fitzroy, Melbourne, Victoria 3065, Australia. catherine.meade@svhm.org.au
Seizure
|September 4, 2007
Summary
This study quantifies rhinal cortex (entorhinal and perirhinal cortices) volumes in epilepsy patients. Morphometric changes in these limbic system structures were observed, linked to disease laterality and potentially cerebral dominance.
Area of Science:
- Neuroimaging
- Epilepsy Research
- Neuroanatomy
Background:
- The rhinal cortex, including the entorhinal (ErC) and perirhinal (PrC) cortices, is a key limbic system component.
- This region is potentially affected in epilepsy and other temporal lobe pathologies.
Purpose of the Study:
- To develop and validate volumetric MRI protocols for measuring ErC and PrC.
- To quantitatively examine the rhinal cortex in patients with temporal lobe epilepsy and mesial temporal sclerosis (MTS).
Main Methods:
- Volumetric analysis of MRI scans using ANALYZE 7.5.
- Detailed anatomical definitions were used for ErC and PrC measurements.
- Study included 61 epilepsy patients (MTS) and 20 controls; high inter-rater reliability was achieved.
Main Results:
- Reduced ipsilateral hippocampal volume in MTS patients; contralateral volume was not significantly different from controls.
- Rhinal cortex volumes (ErC and PrC) were reduced in patients, correlating with disease laterality.
- A significant interaction was found between MTS side, hemisphere, structure, and handedness.
Conclusions:
- This study provides reliable in vivo evidence of morphometric changes in the ErC and PrC in unilateral MTS patients.
- Observed relationships suggest cerebral dominance may modulate MTS expression.
