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Effects of nimodipine on psychological-stress situation in aged rats
V De Marino1, N Pisanti, D Capone
1Department of Human Communicative Sciences, II School of Medicine, University of Naples, Italy.
Acta Neurologica
|October 1, 1991
Abstract:
Female aged rats treated with nimodipine, a calcium-blocker dihydropyridine derivative, were submitted to a psychological-stress situation. Nimodipine at the doses of 3 and 6 mg/Kg antagonized the stress-related body-weight decrease and lethality. These findings seem to validate the role of Ca-mediated mechanisms in the physiopathology of stress and the protective effects of the Ca-blockers in the stress-related illnesses.