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Updated: Jul 12, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Hormone replacement Up-to-date. Adrenopause and DHEA replacement therapy]
Keizo Ohnaka1, Ryoichi Takayanagi
1Kyushu University, Graduate School of Medical Sciences, Department of Geriatric Medicine, Japan.
Serum levels of dehydroepiandrosterone (DHEA) decline with aging, a process known as adrenopause. DHEA replacement therapy shows potential benefits for anti-aging, improving well-being, and metabolism, warranting further research in Japan.
Area of Science:
- Endocrinology
- Gerontology
- Metabolic research
Context:
- Serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels decrease with aging, termed adrenopause.
- DHEA exhibits potential beneficial effects, including anti-diabetic, anti-atherosclerosis, and anti-osteoporosis properties.
- DHEA replacement therapy is explored as an anti-aging intervention.
Purpose:
- To investigate the effects of DHEA replacement therapy.
- To evaluate the efficacy of DHEA in improving well-being, lipid metabolism, and bone metabolism.
- To gather original data to support DHEA replacement therapy in Japan.
Summary:
- Short-term administration of DHEA was studied in healthy Japanese men.
- Previous clinical trials indicated improvements in well-being, lipid, and bone metabolism with DHEA replacement.
- This study contributes to the growing body of evidence for DHEA's therapeutic potential.
Impact:
- Further data accumulation is crucial for promoting DHEA replacement therapy in Japan.
- Findings may inform future clinical guidelines and therapeutic strategies for age-related decline.
- Potential to enhance quality of life and healthspan in aging populations.
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