Related Experiment Video
Updated: Jul 12, 2026
06:36
Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
Published on: August 21, 2020
Happenings in histopathology - a post-World War II perspective
1Department of Pathology, National University of Singapore, Singapore. patshanm@nus.edu.sg
Annals of the Academy of Medicine, Singapore
|September 4, 2007
Summary
Histopathology has advanced significantly since WWII, with new techniques like molecular pathology and telepathology poised to revolutionize the field. These developments impact training, ethics, and global collaboration in diagnostic pathology.
Area of Science:
- Histopathology
- Pathology
- Medical Diagnostics
Background:
- Post-World War II advancements in histopathology practice.
- Review of key developments across four major themes.
Observation:
- New techniques include cytopathology, electron microscopy, immunohistochemistry, and molecular pathology.
- Organizational aspects cover recruitment, training, subspecialties, and quality control.
- Ethical/legal considerations involve service costs and tissue ownership.
- Globalisation encompasses international associations, standardized nomenclature, and telepathology.
Findings:
- Molecular pathology and telepathology represent the most impactful recent advances.
- Significant evolution in diagnostic techniques and practice management.
Implications:
- Future practice of pathology will be heavily influenced by molecular pathology and telepathology.
- Need for updated training, ethical guidelines, and global standards in histopathology.
Related Concept Videos
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
01:24Cirrhosis II: Pathophysiology
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
01:11Healing I: Introduction
Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
01:26Histology of the Large Intestine
The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
01:03Fixation and Sectioning
Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...