Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug-Receptor Interaction: Agonist01:25

Drug-Receptor Interaction: Agonist

Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous ligand's action.
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Drug-Receptor Interactions01:29

Drug-Receptor Interactions

Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue.
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific associations of perioperative Resolvin D1 and D2 dynamics with postoperative atrial fibrillation in cardiac surgery: a secondary analysis of a prospective observational study.

European heart journal open·2026
Same author

Postoperative C-Reactive Protein Resolution Patterns in Patients With and Without Postoperative Atrial Fibrillation After Cardiac Surgery.

Interdisciplinary cardiovascular and thoracic surgery·2026
Same author

Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil-vascular endothelial cell interactions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Sleep disturbance affects inflammatory resolution in Long COVID.

Prostaglandins, leukotrienes, and essential fatty acids·2026
Same author

Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis.

The Journal of clinical investigation·2026
Same author

Nouveau benzo-mimetics of 17R-Resolvin D2 are potent resolution agonists for inflammation.

iScience·2026

Related Experiment Video

Updated: Jul 12, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
07:50

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Published on: July 16, 2012

Endogenous receptor agonists: resolving inflammation.

Gerhard Bannenberg1, Makoto Arita, Charles N Serhan

  • 1Department of Plant Molecular Genetics, Centro Nacional de Biotecnología, CSIC, Madrid, Spain. gbannenberg@cnb.uam.es

Thescientificworldjournal
|September 4, 2007
PubMed
Summary

New lipid mediators, resolvins and protectins, derived from omega-3 polyunsaturated fatty acids (PUFA), actively resolve inflammation. These molecules are crucial for controlling inflammation duration and severity, promoting tissue homeostasis.

Related Experiment Videos

Last Updated: Jul 12, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
07:50

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Published on: July 16, 2012

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • Controlled resolution of inflammation is vital for tissue homeostasis.
  • Aberrant inflammation is implicated in numerous diseases.
  • Understanding molecular mechanisms of inflammation termination is crucial.

Purpose of the Study:

  • Review recent advances in lipid mediators regulating inflammation resolution.
  • Highlight the role of arachidonic acid and omega-3 polyunsaturated fatty acids (PUFA).
  • Focus on novel proresolving mediators like resolvins and protectins.

Main Methods:

  • Functional lipidomic approach using LC-MS-MS-based informatics.
  • Analysis of endogenous lipid mediators in exudates during inflammation resolution.
  • Utilizing animal models to study mediator function.

Main Results:

  • Discovery of new families of local-acting lipid mediators.
  • Identification of resolvins and protectins derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
  • Demonstration that these mediators control inflammation duration and magnitude.

Conclusions:

  • Specific lipid mediators are actively biosynthesized during inflammation resolution.
  • Resolvins and protectins act as endogenous agonists to resolve inflammation.
  • These findings underscore the therapeutic potential of lipid mediators in inflammatory diseases.