Related Experiment Video
Updated: Jul 12, 2026
Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
Published on: February 10, 2013
Gender differences in chronotropic and hemodynamic responses during dobutamine-atropine stress echocardiography
Jeane Mike Tsutsui1, Sandra Nívea Reis Saraiva Falcão, Paulo Magno Martins Dourado
1Heart Institute (InCor), University of São Paulo Medical School, Avenida Dr. Enéas Carvalho de Aguiar 44, São Paulo, Brazil. jeane.tsutsui@incor.usp.br
Aim:
The aim of this study was to determine the influence of gender on chronotropic and hemodynamic response during dobutamine stress echocardiography with early injection of atropine (EA-DSE).
Methods:
From January 2000 to June 2003, we retrospectively evaluated patients who underwent EA-DSE for known or suspected coronary artery disease. We studied 494 patients, 243 men and 251 women, who were not under beta-blocker or calcium channel-blocker therapy (Group A) and 326 patients, 157 men and 169 women, using these medications (Group B). Differences on chronotropic and hemodynamic responses during EA-DSE were assessed by gender in the two groups. Predictors of need for higher doses of dobutamine were determined by multivariate analysis.
Results:
In Group A, higher proportion of women achieved test end points at the stage of 20 mcg/kg per minute. Dobutamine and atropine doses were lower in women than in men (29 +/- 5 versus 31 +/- 6 mcg/kg per minute; P = 0.001 and 0.61 +/- 0.32 versus 0.78 +/- 0.43 mg; P = 0.006). Cardiac chronotropism and systolic blood pressure response patterns differed by gender. In Group B, there was no difference in the proportion of patients who achieved test end points at each stage of dobutamine. The independent predictors of the need for higher doses of dobutamine in Group A were gender [Odds Ratio (OR) = 1.99, 95% Confidence Interval (CI) = 1.19-3.32; P = 0.008], age (OR = 0.91,CI = 0.89-0.93; P < 0.001), and baseline heart rate (OR = 0.95,CI = 0.93-0.98; P < 0.001). Independent predictors in the total population were age (OR = 0.92,CI = 0.90-0.94; P < 0.001), baseline heart rate (OR = 0.95,CI = 0.93-0.97; P < 0.001), and beta-blocker therapy (OR = 0.42,CI = 0.18-1.51; P = 0.04).
Conclusion:
Gender has influence on heart rate and blood pressure response to the EA-DSE in patients without use of drugs with negative chronotropic effects.
Related Concept Videos
01:26Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...