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HLA-A*020115 and HLA-Cw*030203 show new synonymous mutations in exon 4

A Balas1, L Bustamante, F García-Sánchez

  • 1Departamento de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, 20832 Madrid, Spain. abalas.trans@salud.madrid.org

Tissue Antigens
|September 5, 2007
PubMed

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...