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A novel HLA-C allele, Cw*0119, isolated from the Han Chinese

L Ding1, W Z Lin, Y P Wu

  • 1Department of Biochemistry, College of Life Sciences, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, China.

Tissue Antigens
|September 5, 2007
PubMed

Insights

A new Human Leukocyte Antigen-C (HLA-C) allele, named Cw*0119, was discovered in a Han Chinese individual. This novel allele presents distinct genetic variations at codons 76 and 178 compared to the known Cw*010201 allele.

Area of Science:

  • Immunogenetics
  • Molecular Anthropology

Background:

  • Human Leukocyte Antigen (HLA) genes are crucial for immune response.
  • HLA-C alleles exhibit significant diversity across global populations.
  • Understanding HLA polymorphism is vital for transplantation and disease association studies.

Purpose of the Study:

  • To report the identification and characterization of a novel HLA-C allele.
  • To describe the specific genetic differences of this new allele.

Main Methods:

  • DNA sequencing of the HLA-C gene.
  • Bioinformatic analysis to compare the novel sequence with existing HLA databases.

Main Results:

  • A novel HLA-C allele, designated Cw*0119, was identified in an individual of Han Chinese ancestry.
  • Cw*0119 differs from the reference allele Cw*010201 by two nucleotide substitutions: AGC to TGC at codon 76 and CTG to CCG at codon 178.

Conclusions:

  • The discovery of Cw*0119 expands the known repertoire of HLA-C alleles.
  • This finding contributes to the detailed cataloging of HLA genetic diversity within the Han Chinese population.

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