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Related Experiment Videos

Vertebrate craniofacial development: the relation between ontogenetic process and morphological outcome.

D M Noden1

  • 1Department of Anatomy, College of Veterinary Medicine, Cornell University, Ithaca, NY.

Brain, Behavior and Evolution
|January 1, 1991
PubMed
Summary

Vertebrate embryonic head development involves complex cell migrations and tissue interactions, revealing intricate patterns of craniofacial morphogenesis. Understanding these dynamic processes, guided by gene expression, is key to deciphering developmental mechanisms.

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Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Genetics

Background:

  • Segmental organization is a hallmark of vertebrate embryonic head structures, including the hindbrain, paraxial mesoderm, and neural crest cells.
  • Ventral and lateral head structures like epibranchial placodes, aortic arches, and pharyngeal pouches also exhibit serial arrangement.
  • These embryonic structures are crucial for defining homologies in comparative morphology.

Purpose of the Study:

  • To detail the complex cell movements and tissue lineages in vertebrate craniofacial development.
  • To explore how extensive cell migrations influence tissue interactions and developmental patterns.
  • To integrate cellular and molecular data for a comprehensive understanding of craniofacial morphogenesis.

Main Methods:

Related Experiment Videos

  • Utilizing new cell labeling and identification techniques to track cell movements and lineages.
  • Analyzing gene expression patterns, including homeobox genes, during gastrula, neurula, and early organogenesis stages.
  • Conducting comparative morphological studies augmented by molecular data.

    • Main Results:

    • Documenting dramatic cell movements of neural crest, neural plate, myoblasts, angioblasts, and placode-derived cells.
    • Revealing diverse migratory behaviors, from directed pathways to invasive wandering.
    • Identifying that rearrangements complicate analyses of segmental relations due to cells originating from multiple axial levels.
    • Highlighting the role of homeobox genes in establishing spatial identity, similar to Drosophila.

    Conclusions:

    • Extensive morphogenetic movements in vertebrate craniofacial development bring cells into novel tissue and matrix environments.
    • The complex rearrangements challenge traditional analyses of segmental relationships.
    • Combining cellular and molecular studies offers opportunities to understand gene expression and morphogenesis.
    • This research provides a basis for testing hypotheses on the mechanisms controlling cell movement and tissue assembly in craniofacial development.