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Related Experiment Videos

Growth hormone physiology: current concepts.

P M Martha1, R J Krieg

  • 1Department of Pediatrics, Baystate Medical Center, Springfield, Mass.

Child Nephrology and Urology
|January 11, 1991
PubMed
Summary
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Growth hormone (GH) impacts kidney function and is regulated by the hypothalamus. Its varied molecular forms and episodic release patterns, influenced by age, are crucial for childhood and adolescent growth.

Area of Science:

  • Endocrinology
  • Physiology
  • Molecular Biology

Background:

  • Growth hormone (GH) plays a vital role in numerous physiological processes, including kidney function.
  • GH is secreted by pituitary cells, with its activity primarily controlled by hypothalamic neurohormones.
  • GH exists in diverse molecular forms and circulates freely or bound to binding proteins, influencing its clearance and action.

Purpose of the Study:

  • To explore the multifaceted nature of Growth Hormone (GH).
  • To understand the regulation and physiological impact of GH, particularly its molecular heterogeneity and secretory patterns.
  • To highlight the significance of GH secretory dynamics in human growth during development.

Main Methods:

  • Review of existing literature on GH secretion, regulation, and molecular forms.

Related Experiment Videos

  • Analysis of GH's interaction with GH binding proteins and its mediation through insulin-like growth factors.
  • Examination of the episodic secretory patterns of GH and their age-related changes.

    • Main Results:

    • GH influences renal plasma flow and glomerular filtration rate.
    • Human GH comprises at least 20 molecular forms, with 22 kDa and 20 kDa monomers being most common.
    • GH binding proteins affect GH clearance and tissue-level actions.
    • GH effects are largely mediated by insulin-like growth factors.
    • GH secretion is episodic, with patterns changing with age.

    Conclusions:

    • The complex molecular forms and episodic secretory patterns of GH are critical for normal growth in children and adolescents.
    • Understanding GH regulation and action is essential for comprehending overall physiological function.
    • GH binding proteins and insulin-like growth factors are key components in mediating GH's diverse effects.