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History of the development of pertussis vaccine
1Center for Biologics Evaluation and Research, USA Food and Drug Administration, Bethesda, MD 20892.
Abstract:
Bordetella pertussis and the disease whooping cough have mysterious unique features among bacterial infectious diseases. Numerous studies gradually provided information that permitted the development of a pertussis vaccine and the assessment of its potency relative to human efficacy. The advances in the understanding of B. pertussis, its pathogenicity and immunity that led to the development of a pertussis vaccine are presented.