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Published on: January 7, 2019
A silver bullet for the treatment of depression?
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA. ronald.duman@yale.edu
Abstract:
The search for a rapid-acting antidepressant has been a subject of intense research interest for several decades. The article by Lucas and colleagues in this issue of Neuron provides compelling evidence from preclinical animal models that drugs acting at the serotonin 5-HT(4) receptor could finally achieve this goal. However, caution is warranted, as results from animal studies are not always predictive of therapeutic actions in humans.
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