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Effector memory CD8+ T cells are resistant to apoptosis

Sudhir Gupta1, Sastry Gollapudi

  • 1Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA. sgupta@uci.edu

Annals of the New York Academy of Sciences
|September 6, 2007
PubMed

Based upon their migrating properties and effector functions, CD8(+) T cells have been further classified into central memory (T(CM)) and two types of effector memory (T(EM) and T(EMRA)) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeostasis, we have examined the relative sensitivity of naïve (T(N)) and different memory CD8(+) T cells to apoptosis. We show that both T(EM) and T(EMRA) CD8(+) T cells are resistant to apoptosis, whereas T(N) and T(CM) CD8(+) T cells are sensitive to apoptosis.

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