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Recurrence in supratentorial anaplastic ependymoma
Raj Kumar1, Namit Singhal, Shishir K Jaiswal
1Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. rajkumar@sgpgi.ac.in
Pediatric Neurosurgery
|September 6, 2007
Summary
Supratentorial anaplastic ependymomas are aggressive brain tumors with high recurrence rates. Even with complete surgical removal and radiation, early recurrence is common, necessitating further research into effective treatments.
Area of Science:
- Pediatric neuro-oncology
- Neurosurgery
- Radiation oncology
Background:
- Supratentorial anaplastic ependymoma is an aggressive primary brain tumor.
- Understanding its behavior and treatment outcomes is crucial for improving patient prognosis.
Purpose of the Study:
- To investigate the clinical outcomes and recurrence patterns of supratentorial anaplastic ependymoma.
- To evaluate the effectiveness of current treatment modalities.
Main Methods:
- Retrospective review of 16 cases of supratentorial anaplastic ependymoma.
- Analysis of patient demographics, treatment received, and follow-up data.
- Assessment of recurrence rates and time to recurrence.
Main Results:
- Gross total tumor excision was achieved in 14 cases.
- Twelve of 14 treated cases recurred, with recurrence noted between 6 and 58 months post-treatment.
- Only two patients remained recurrence-free at short-term follow-up.
Conclusions:
- Anaplastic ependymomas are highly aggressive, with frequent recurrences despite maximal surgical resection and radiotherapy.
- Current treatment strategies appear insufficient to prevent early recurrence.
- Further investigation into factors influencing outcomes and novel therapeutic approaches is warranted.
