Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Naturalistic Observations02:30

Naturalistic Observations

If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing tokenism in patient and public involvement by integrating the Gothenburg person-centred care framework, relational bridges and impact log - a co-produced position paper.

Research involvement and engagementยท2026
Same author

Translating the Living with Medicines Questionnaire from English to Swedish: a validation study.

Scandinavian journal of public healthยท2026
Same author

Telephone Outreach Is Associated With Improved Blood Pressure in Patients at an Urban Community Health Center.

Journal of primary care & community healthยท2026
Same author

Telephone Outreach and Skill-Based Group Education Improves Blood Pressure in Patients at a Community Health Center.

Public health nursing (Boston, Mass.)ยท2026
Same author

Psychometric Properties of the Mental Health Help-Seeking Scale Among Nursing Students.

Nursing education perspectivesยท2026
Same author

Making Value Visible Through Measurement: Creating Actionable Measurement Maps for Nursing Care Processes and Outcomes.

AACN advanced critical careยท2026

Related Experiment Video

Updated: Jul 12, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

A practical use of theory to study adherence.

Bradi B Granger1, Debra Moser, Joanne Harrell

  • 1Duke University Health Systems, Duke University School of Nursing, Durham, NC, USA. grang004@mc.duke.edu

Progress in Cardiovascular Nursing
|September 6, 2007
PubMed
Summary

Nonadherence to chronic heart failure (CHF) regimens is a major cause of costly hospitalizations. The Trajectory Theory of Chronic Illness offers a new framework to understand patient adherence over time.

More Related Videos

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

Related Experiment Videos

Last Updated: Jul 12, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

Area of Science:

  • Cardiology
  • Healthcare Management
  • Nursing

Background:

  • Chronic heart failure (CHF) incurs significant healthcare costs, largely due to hospitalizations for acute symptoms.
  • Nonadherence to prescribed treatment regimens is the primary preventable cause of rehospitalization in CHF patients.
  • Existing theoretical models for adherence often overlook the complexities of self-care in chronic illness management.

Purpose of the Study:

  • To operationalize the Trajectory Theory of Chronic Illness for studying adherence in heart failure patients.
  • To explore how the trajectory model can enhance understanding of patient adherence over time.
  • To provide a framework for improving patient adherence to CHF self-care regimens.

Main Methods:

  • This paper presents a conceptual approach for applying the Trajectory Theory of Chronic Illness.
  • The focus is on evaluating patient attributes within the context of the work required for adherence.
  • The model is proposed as a tool for research into adherence behaviors.

Main Results:

  • The trajectory model provides a clearer evaluation of patient attributes when adherence work is considered over time.
  • It offers a unique perspective on the challenges and demands of complex self-care regimens.
  • This approach facilitates a deeper understanding of adherence in chronic illness.

Conclusions:

  • The Trajectory Theory of Chronic Illness offers a valuable framework for studying adherence in heart failure.
  • Understanding the 'work' of adherence is crucial for developing effective interventions.
  • This theoretical approach can help healthcare providers better support patient adherence to CHF management plans.