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Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

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Published on: June 2, 2015

Angiogenesis modulates adipogenesis and obesity.

¹Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden. yihai.cao@ki.se

The Journal of Clinical Investigation

|September 6, 2007

Summary

Obesity involves coupled fat cell growth and new blood vessel formation. Targeting angiogenesis, the process of new blood vessel growth, offers a potential treatment for obesity and related conditions.

Area of Science:

Biomedical science
Cell biology
Physiology

Background:

Neoplastic and nonneoplastic tissue growth rely on angiogenesis.
Neovascularization and adipogenesis are linked from prenatal development through adult life.
Paracrine signaling systems mediate interactions between neovascularization and adipogenesis.

Purpose of the Study:

To investigate the relationship between adipogenesis and angiogenesis.
To explore the role of angiogenic factors produced by adipocytes.
To evaluate antiangiogenic agents as a therapeutic strategy for obesity.

Main Methods:

Review of existing evidence on angiogenesis and adipogenesis.
Analysis of paracrine signaling pathways involved in fat mass expansion.

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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Assessment of the therapeutic potential of antiangiogenic agents.

Main Results:

Activated adipocytes secrete multiple angiogenic factors (leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, TGF-beta).
These factors stimulate neovascularization during fat mass expansion.
The interplay between adipogenesis and neovascularization is crucial for obesity development.

Conclusions:

Antiangiogenic agents represent a novel therapeutic approach for obesity.
Targeting angiogenesis could prevent and treat human obesity and associated disorders.