Related Experiment Video
Updated: Jul 12, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Prediction of pharmaceutical solubility Via NRTL-SAC and COSMO-SAC
Hsien-Hsin Tung1, Jose Tabora, Nara Variankaval
1Merck Research Laboratories, 127 E Lincoln Ave., Rahway, New Jersey 07065, USA. Hsien_Hsin_Tung@Merck.com
Abstract:
Solid phase solubility is a fundamental parameter in the design of crystallization processes. The development and optimization of crystallization processes requires screening of numerous solvent systems for which the solubility of the compound of interest has to be measured as a function of temperature and solvent composition. Tools that quickly estimate the solubility in different solvents can be very useful in the initial phases of the solvent system selection process. In this paper, we report our experience applying two thermodynamic models in the solubility estimation of pharmaceutical compounds: the NRTL-SAC method (Chen and Song, 2004, Ind Eng Chem Res 43: 8354) which provides a correlative and predictive model from limited solubility measurements, and the COSMO-SAC (Lin and Sandler, 2002, Ind Eng Chem Res 41: 899) method which predicts solubility from ab initio calculations. These theoretical methods, coupled with rapid experimental measurement for verification, provide a powerful solubility screening protocol for the development of crystallization processes.
More Related Videos
05:08Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
10:12Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Related Concept Videos
Solubility
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Factors Influencing Drug Absorption: Drug Dissolution
Bioavailability Enhancement: Drug Solubility Enhancement
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Factors Affecting Solubility