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Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination
S Nakajima1, K Niiyama, M Ihara
1Central Research, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|December 1, 1991
Abstract:
The structures of novel endothelin-binding inhibitors, BE-18257A and BE-18257B, were elucidated by spectral analyses and chemical studies. Both inhibitors were found to have a cyclic pentapeptide structure containing three D-form amino acid residues, namely, the structures of BE-18257A and BE-18257B were elucidated to be cyclo(-D-Glu-L-Ala-D-Val-L-Leu-D-Trp-) and cyclo(-D-Glu-L-Ala-allo-D-Ile-L-Leu-D-Trp-), respectively.