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[Adrenocortical carcinoma and its treatment with mitotane. Description of a case]
1III Divisione Medica, Ospedale di Cattinara, Trieste.
Minerva Medica
|December 1, 1991
Abstract:
Adrenocortical carcinoma is a rare tumor with a poor prognosis. The clinical features and rational bases of pharmacologic therapy of adrenocortical carcinoma are discussed in the light of the case of a patient with a bulky, inoperable tumor whose treatment with mitotane was followed by a dramatic regression though several, important side effects.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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