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Published on: January 19, 2014
RESPONSES OF SHEEP TO ZYGADENUS GRAMINEUS, "DEATH CAMAS".
Science (New York, N.Y.)
|January 30, 1931
Summary
Zygadenus gramineus (death camas) extract causes respiratory inhibition and asphyxia-like symptoms in sheep. Caffein sodio-benzoate shows potential as a respiratory stimulant, offering a possible antidote.
Area of Science:
- Veterinary Toxicology
- Pharmacology
Background:
- Zygadenus gramineus, commonly known as death camas, is a toxic plant.
- The toxicological effects of Zygadenus gramineus on mammalian respiration and circulation are not fully understood.
Purpose of the Study:
- To investigate the physiological effects of a resin-depleted Zygadenus gramineus extract on sheep.
- To evaluate the potential of caffein sodio-benzoate as an antidote for Zygadenus gramineus poisoning.
Main Methods:
- Intravenous administration of Zygadenus gramineus extract to sheep.
- Monitoring of blood pressure and respiratory movements.
- Experimental induction of asphyxia by tracheal cannula occlusion for comparison.
Main Results:
- Intravenous injection of the extract induced significant respiratory inhibition.
- Higher doses led to asphyxia-like increases in blood pressure.
- Tracheal cannula occlusion mimicked the observed asphyxial effects.
- Caffein sodio-benzoate demonstrated marked stimulation of the respiratory center.
Conclusions:
- Zygadenus gramineus extract possesses potent respiratory depressant properties.
- Caffein sodio-benzoate may serve as a valuable stimulant for the respiratory center in cases of Zygadenus gramineus poisoning.
