Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epiphytes, Parasites, and Carnivores02:40

Epiphytes, Parasites, and Carnivores

16.9K
Plants often form mutualistic relationships with soil-dwelling fungi or bacteria to enhance their roots’ nutrient uptake ability. Root-colonizing fungi (e.g., mycorrhizae) increase a plant’s root surface area, which promotes nutrient absorption. While root-colonizing, nitrogen-fixing bacteria (e.g., rhizobia) convert atmospheric nitrogen (N2) into ammonia (NH3), making nitrogen available to plants for various biological functions. For example, nitrogen is essential for the...
16.9K
Structure and Function of Platelets01:18

Structure and Function of Platelets

3.7K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.7K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

9.4K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
9.4K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.6K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.6K
Symbiosis00:58

Symbiosis

37.6K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
37.6K
Correlation and Causation01:27

Correlation and Causation

42.9K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more.

medRxiv : the preprint server for health sciences·2023
Same author

Concerning one case of rupture of a flow regulator: How patient safety procedures contribute to the correct use of medical devices.

Die Pharmazie·2022
Same author

Costs and management of patients with hemophilia A in France: the Hemraude study.

The European journal of health economics : HEPAC : health economics in prevention and care·2021
Same author

[Toxoplasmosis in pregnancy: Practical Management].

Gynecologie, obstetrique, fertilite & senologie·2021
Same author

Autochthonous and persistent cutaneous larva migrans in an infant successfully treated by topic albendazole ointment.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

Corrigendum to "Effect of double-filtration plasmapheresis for antibody-mediated rejection on hemostasis parameters and thrombin generation" [Thromb. Res. 166 (2018) 113-121].

Thrombosis research·2018

Related Experiment Video

Updated: Feb 10, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.1K

Platelet cytotoxicity against parasites.

B Polack1, F Peyron, C Auriault

  • 1Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, CHRU, Grenoble, France.

Nouvelle Revue Francaise D'Hematologie
|January 1, 1991
PubMed
Summary

Platelets exhibit cytotoxic functions against parasites, acting beyond their role in hemostasis. This parasiticidal activity, mediated by antibodies or parasites, suggests a link between hemostasis and inflammation.

Area of Science:

  • Immunology
  • Hematology
  • Parasitology

Background:

  • Platelets are primarily known for hemostasis and thrombosis.
  • Emerging evidence suggests platelets play roles in immune defense, particularly against parasitic infections.

Purpose of the Study:

  • To explore the cytotoxic functions of platelets against parasites.
  • To investigate the mechanisms underlying platelet-mediated parasiticidal activity.
  • To understand the relationship between platelet functions in hemostasis and immunity.

Main Methods:

  • In vitro and in vivo assays to assess platelet cytotoxicity.
  • Analysis of mechanisms involving antibodies and direct parasite interaction.
  • Investigation of shared metabolic pathways in hemostasis and cytotoxicity.

More Related Videos

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.7K

Related Experiment Videos

Last Updated: Feb 10, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.1K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.7K

Main Results:

  • Platelets demonstrate cytotoxic effects against both extracellular and intracellular parasites.
  • Parasiticidal activity can be mediated by specific antibodies or directly by the parasite.
  • Metabolic pathways involved in hemostasis appear to be implicated in platelet cytotoxicity.

Conclusions:

  • Platelets possess significant parasiticidal capabilities beyond hemostasis.
  • Platelet cytotoxicity against parasites involves antibody-dependent and direct mechanisms.
  • Primary hemostasis and platelet cytotoxicity represent specialized inflammatory responses.