[Protective effect of anti-staphylococcal immunosorbent on the phenotype of lymphocyte membrane in diffuse...

An antistaphylococcal and an antitetanic immunosorbents on a silica carrier were tested in diffuse staphylococcal pyocyanic peritonitis to protect receptor expression on the general T and B lymphocyte populations and of Fc-receptors to IgM, IgG and IgA. Plasma of animals with peritonitis was shown to exert a powerful suppressive effect on lymphocyte receptors. Perfusion of toxic plasma over the antistaphylococcal immunosorbents resulted in specific adsorption of microbial toxins and completely prevented Fc gamma-, Fc mu- and Fc alpha-receptor expression on cells. Plasma treated with the antitetanic immunosorbent retained suppressive effects. The low protection of receptors may be explained by nonspecific adsorption of texins.