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[Sensitivity of Pseudomonas mallei to fluoroquinolones and their efficacy in experimental glanders]
Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
|September 1, 1991
Abstract:
Thirteen strains of P. mallei were found to be highly sensitive to ciprofloxacin and ofloxacin and resistant to norfloxacin. Ciprofloxacin and ofloxacin showed a high efficacy on models of malleus in guinea pigs and hamsters. The animals were infected with various strains of P. mallei. In the in vitro experiments, ciprofloxacin proved to be the most active and efficient. Norfloxacin appeared to be inefficient.
Insights
Ciprofloxacin and ofloxacin are effective against Pseudomonas mallei infections, demonstrating high efficacy in animal models and in vitro. Norfloxacin proved ineffective against this bacterium.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Context:
- Pseudomonas mallei (P. mallei) is a Gram-negative bacterium responsible for glanders, a zoonotic disease.
- Antibiotic resistance in P. mallei poses a significant challenge for treatment and disease control.
- Fluoroquinolones are a class of antibiotics commonly used to treat bacterial infections.
Purpose:
- To evaluate the in vitro and in vivo efficacy of ciprofloxacin, ofloxacin, and norfloxacin against P. mallei.
- To determine the susceptibility patterns of P. mallei strains to these fluoroquinolone antibiotics.
Summary:
- Thirteen P. mallei strains exhibited high sensitivity to ciprofloxacin and ofloxacin, but resistance to norfloxacin.
- Both ciprofloxacin and ofloxacin demonstrated high efficacy in guinea pig and hamster models of malleus (glanders).
- In vitro testing confirmed ciprofloxacin as the most active and efficient agent, while norfloxacin was found to be inefficient.
Impact:
- Ciprofloxacin and ofloxacin represent promising therapeutic options for treating P. mallei infections.
- The findings provide crucial data for guiding antibiotic selection in glanders management.
- Understanding fluoroquinolone efficacy is vital for combating P. mallei and preventing zoonotic transmission.