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Risperidone-induced enuresis in two children with autistic disorder
Sabri Hergüner1, Nahit Motavalli Mukaddes
1Department of Child and Adolescent Psychiatry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. cocukergen@yahoo.com
Journal of Child and Adolescent Psychopharmacology
|September 8, 2007
Summary
Risperidone can cause enuresis (incontinence) in children with autism. Switching to olanzapine resolved this side effect, suggesting it as a viable alternative treatment for managing behavioral issues.
Area of Science:
- Neuroscience
- Pediatric Psychiatry
- Pharmacology
Background:
- Risperidone is frequently used for behavioral problems in autistic children.
- Common side effects include weight gain and sedation, but enuresis is rarely reported.
Observation:
- Two pediatric cases of new-onset enuresis (diurnal and nocturnal) during risperidone monotherapy are presented.
- Patients diagnosed with autism and mental retardation developed enuresis within weeks of starting risperidone.
Findings:
- Enuresis resolved rapidly after discontinuing risperidone and switching to olanzapine.
- No recurrence of enuresis was observed with olanzapine treatment for up to one year.
Implications:
- Antipsychotic-induced enuresis may be linked to alpha(1)-adrenergic blockade and dopaminergic effects.
- Switching to olanzapine, with its lower blockade properties, is a potential alternative for risperidone-induced enuresis.
- Clinicians should monitor for enuresis, particularly in pediatric populations with developmental disabilities.
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