Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visualizing cellular G-quadruplexes with a bioinspired chemiluminescent probe.

Nucleic acids research·2026
Same author

The presence and impact of G-quadruplexes in plant chloroplast DNA.

BMC plant biology·2026
Same author

CRISPR-Cas9-mediated upregulation of utrophin ameliorates Duchenne muscular dystrophy.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

High-throughput measurement and prediction of the i-motif DNA stability landscape.

Nucleic acids research·2026
Same author

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life.

Nucleic acids research·2026
Same author

Designing an ecofriendly catalyst for a sustainable use of water resources.

National science review·2026

Related Experiment Video

Updated: Jul 11, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Targeting telomeres and telomerase.

Anne De Cian1, Laurent Lacroix, Céline Douarre

  • 1INSERM, U565, Acides nucléiques: dynamique, ciblage et fonctions biologiques, 43 rue Cuvier, CP26, Paris Cedex 05, F-75231, France.

Biochimie
|September 8, 2007
PubMed
Summary
This summary is machine-generated.

Telomeres and telomerase are promising cancer therapy targets. This review focuses on G-quadruplex ligands as telomerase inhibitors and their potential in oncology.

More Related Videos

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Droplet Digital TRAP (ddTRAP): Adaptation of the Telomere Repeat Amplification Protocol to Droplet Digital Polymerase Chain Reaction
06:38

Droplet Digital TRAP (ddTRAP): Adaptation of the Telomere Repeat Amplification Protocol to Droplet Digital Polymerase Chain Reaction

Published on: May 3, 2019

Related Experiment Videos

Last Updated: Jul 11, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Droplet Digital TRAP (ddTRAP): Adaptation of the Telomere Repeat Amplification Protocol to Droplet Digital Polymerase Chain Reaction
06:38

Droplet Digital TRAP (ddTRAP): Adaptation of the Telomere Repeat Amplification Protocol to Droplet Digital Polymerase Chain Reaction

Published on: May 3, 2019

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Telomeres protect chromosome ends, and their maintenance by telomerase is crucial for cancer cell proliferation.
  • Telomerase activity is dysregulated in most human cancers, making it a prime target for therapeutic intervention.
  • Understanding telomere biology and telomerase function is key to developing novel anti-cancer strategies.

Purpose of the Study:

  • To review the latest mechanisms of action for telomerase inhibitors.
  • To highlight G-quadruplex ligands as a specific class of telomere-targeting agents.
  • To discuss the potential clinical applications of these inhibitors in cancer treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on telomerase inhibitors.
  • Focus on G-quadruplex ligands and their interaction with telomeric DNA.
  • Analysis of data regarding the efficacy and safety of these agents in cancer models.

Main Results:

  • Telomerase inhibitors, particularly G-quadruplex ligands, demonstrate potent anti-cancer activity by disrupting telomere maintenance.
  • These ligands stabilize G-quadruplex structures in telomeric DNA, inhibiting telomerase function.
  • Evidence suggests a strong correlation between G-quadruplex ligand efficacy and telomere length/telomerase activity in cancer cells.

Conclusions:

  • G-quadruplex ligands represent a promising class of telomerase inhibitors for cancer therapy.
  • Targeting telomeres and telomerase offers a viable strategy to combat cancer.
  • Further research and clinical trials are warranted to fully explore the therapeutic potential of G-quadruplex ligands in oncology.