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Related Concept Videos

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Related Experiment Video

Updated: May 3, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
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Phenotypic changes induced by IL-12 priming regulate effector and memory CD8 T cell differentiation.

Jee-Boong Lee1, Kyoo-A Lee, Jun Chang

  • 1College of Pharmacy, Ewha Womans University, 11-1 Dae-Hyun Dong, Seo-Dae-Mun Gu, Seoul 120-750, Republic of Korea.

International Immunology
|September 8, 2007
PubMed
Summary
This summary is machine-generated.

Interleukin-12 (IL-12) enhances CD8 T cell survival and differentiation into memory cells, partly through inducing Interleukin-10 (IL-10) expression. IL-10 directly promotes CD8 T cell survival and effector/memory cell populations.

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Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Biology

Background:

  • T-cell receptor (TCR) and co-stimulatory signals are crucial for CD8 T cell activation.
  • Inflammatory cytokines, like IL-12, significantly influence CD8 T cell differentiation and survival.

Purpose of the Study:

  • To elucidate the mechanisms by which IL-12 priming enhances CD8 T cell activation and survival.
  • To identify genes and markers differentially regulated by IL-12 during antigenic stimulation.

Main Methods:

  • Investigated gene and marker regulation by IL-12 in activated CD8 T cells.
  • Analyzed CD127 expression levels and IL-10 induction.
  • Performed adoptive transfer experiments to assess IL-10 priming effects on CD8 T cells.

Main Results:

  • IL-12 priming increased the subpopulation of CD127(hi) cells, which develop into long-lived memory cells.
  • IL-12 priming induced IL-10 expression in activated CD8 T cells, independent of CD127 up-regulation.
  • Direct IL-10 priming significantly increased effector and memory CD8 T cell populations post-transfer, enhancing survival and reducing apoptosis.

Conclusions:

  • IL-10 directly promotes CD8 T cell survival and the generation of effector and memory cells.
  • IL-12 utilizes both IL-10-dependent and independent pathways to regulate CD8 T cell differentiation and survival.
  • Findings reveal a novel, pro-survival role for IL-10 in CD8 T cell responses, distinct from its known immunosuppressive functions.