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Related Experiment Video

Updated: Jul 11, 2026

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
05:35

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Prostate biopsy strategies.

Joseph C Presti1

  • 1Stanford Cancer Center, Stanford, CA 94305-5826, USA. jpresti@stanford.edu

Nature Clinical Practice. Urology
|September 8, 2007
PubMed
Summary

Early prostate cancer detection relies on accurate diagnosis through prostate specific antigen (PSA) testing and biopsies. Recommended strategies include extended schemes for initial biopsies and targeted approaches for repeat biopsies.

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Area of Science:

  • Urology
  • Oncology
  • Diagnostic Medicine

Background:

  • Early prostate cancer detection is crucial for effective patient management.
  • Prostate specific antigen (PSA) and prostate biopsy are key diagnostic tools.

Purpose of the Study:

  • To review the evolution of prostate biopsy strategies.
  • To recommend optimal biopsy schemes for initial and repeat procedures.

Main Methods:

  • Review of historical prostate biopsy techniques.
  • Analysis of diagnostic yield based on biopsy schemes.
  • Focus on extended and saturation biopsy approaches.

Main Results:

  • Extended biopsy schemes (10-12 cores) are recommended for initial biopsies.
  • Repeat biopsies require attention to the anterior apex.
  • Saturation biopsies are advised for patients with multiple negative prior biopsies.

Conclusions:

  • Optimized prostate biopsy strategies improve diagnostic accuracy.
  • Specific approaches are necessary for initial versus repeat biopsies.
  • Understanding histological findings like high-grade prostatic intraepithelial neoplasia impacts repeat biopsy success.

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