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Contributions to biorheology during hemodialysis
U T Seyfert1, W Hauck, J Kirsch
1Abt. für Klinische Hämostaseologie und Transfusionsmedizin, Unikliniken, Homburg/Saar, FRG.
Biorheology
|January 1, 1991
Summary
Foreign surfaces can trigger blood clotting (thrombogenicity). This study found hemofiltration rate significantly increases blood viscosity during hemodialysis, impacting flow, especially with transfusions.
Area of Science:
- Biomaterials Science
- Nephrology
- Hematology
Background:
- Thrombogenicity, the induction of blood clotting on foreign surfaces, is influenced by anticoagulation, rheology, and material properties.
- Chronic renal failure and hemodialysis introduce complexities to blood-surface interactions.
Purpose of the Study:
- To investigate the impact of chronic renal failure, hemodialyzers, and blood transfusion therapy on hemorheological parameters during hemodialysis.
- To understand how these factors influence blood flow behavior and thrombogenicity.
Main Methods:
- Hemodynamic parameters were analyzed in patients undergoing hemodialysis.
- The influence of different hemodialyzer membranes, hemofiltration rates, and blood transfusion therapy was assessed.
- Viscosity and flow behavior were key metrics.
Main Results:
- Hemodialyzer membranes could not be differentiated based on the hemorheological parameters measured.
- A strong correlation was observed between the hemofiltration rate and increased blood viscosity.
- Blood transfusion therapy and elevated hematocrit, particularly with high hemofiltration rates, significantly affected blood flow, especially in microcirculation.
Conclusions:
- Hemofiltration rate is a critical factor influencing blood viscosity during hemodialysis.
- Blood transfusion and hematocrit levels interact with hemofiltration to alter blood flow dynamics.
- Further research is needed to fully elucidate the interplay of these factors in thrombogenicity during hemodialysis.