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Updated: Jul 11, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana
Krishna Prasad Devkota1, Bruno Ndjakou Lenta, Muhammad Iqbal Choudhary
1Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany. devkotakpd@yahoo.com
Abstract:
Bioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids N(a)-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC(50) 2.9-34.1 microM) and butyrylcholinesterase (IC(50) 0.3-3.6 microM). These compounds also showed moderate antiplasmodial activity (IC(50) 2.4-10.3 microM) against the Plasmodium falciparum chloroquine resistant W2 strain.
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