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Updated: Jul 11, 2026
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Solubility and dissolution profile assessment in drug discovery
Kiyohiko Sugano1, Arimichi Okazaki, Shohei Sugimoto
1Global Research & Development, Nagoya Laboratories, Pharmaceutical R&D, Pfizer Inc., Aichi, Japan. Kiyohiko.Sugano@pfizer.com
Drug Metabolism and Pharmacokinetics
|September 11, 2007
Summary
This review introduces the science of drug solubility and dissolution, covering assessment technologies and best practices for oral absorption in drug discovery. It highlights advancements in laboratory automation and computational methods for improved strategies.
Area of Science:
- Pharmacokinetics and Drug Metabolism
- Physical Chemistry in Drug Development
Background:
- Understanding drug solubility and dissolution is crucial for predicting oral absorption.
- Physiological conditions in the gastrointestinal tract influence drug behavior.
- Drug discovery necessitates robust methods for solubility and dissolution assessment.
Purpose of the Study:
- To provide an introduction to the state-of-the-art sciences of solubility and dissolution.
- To present typical technologies used for assessing solubility and dissolution.
- To propose best practice strategies for applying these technologies in drug discovery.
Main Methods:
- Review of scientific literature on solubility and dissolution theories.
- Summary of physiological conditions in the human and animal gastrointestinal tract.
- Introduction to technologies for solubility and dissolution assessment, including automation and computational approaches.
Main Results:
- The review covers fundamental theories of solubility and dissolution relevant to oral absorption.
- Key technologies for assessing these properties in drug discovery are detailed.
- Recent advancements in laboratory automation and computational technologies are highlighted.
Conclusions:
- Effective drug discovery requires a thorough understanding of solubility and dissolution principles.
- Modern technologies enhance the accuracy and efficiency of solubility and dissolution testing.
- Strategic application of these technologies is vital for successful drug development projects.
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