[Clinico-pathologic studies of 95 cases of Hodgkin's disease]

From 1961 through 1986, 95 cases of Hodgkin's disease were biopsied in our hospital. Sex distribution: male 70, female 25. Age incidence: 27% were under 20 years and 75% under 40. 93% of lesions had originated from the lymph nodes. Clinical stage: I 14, II 37, III 25 and IV 19 cases. 20 patients were treated by chemotherapy, 26 by radiotherapy and 49 by combined chemotherapy and radiotherapy. The CR + PR rate was 86.2% and the 1-, 3-, 5- and 10-year survival rates were 83.2% (79/95), 57.6% (53/92), 46.4% (32/69) and 31.3% (15/48), respectively. The results showed that the 4 pathological types (LP, NS, MC, LD) and 10 subtypes (D,N in LP; LP, MC, LD in NS; LP, MC, LD in MC; R, DF in LD) and the predominance of reticulum cells (S-R cells, HD cells, histiocytes, lymphocytes, fibrosis, collagenous changes) in the tumor were all irrelevant to the prognosis (P greater than 0.05). However, the clinical stage, immediate response and the method of treatment were very prognostic (P less than 0.05) The authors believe that intensive chemotherapy combined with radiotherapy and intensive radiotherapy could lead to long survival.