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Updated: Jul 11, 2026

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
Published on: April 26, 2024
Memory CD8+ T cell differentiation in viral infection: a cell for all seasons
Henry Radziewicz1, Luke Uebelhoer, Bertram Bengsch
1Emory University School of Medicine, 954 Gatewood Road, NE, Atlanta, GA 30329, United States.
Abstract:
Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus-specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.
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