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Correction.

M J Welsh, M P Anderson

    Science (New York, N.Y.)
    |December 11, 1992
    PubMed
    Summary
    This summary is machine-generated.

    A correction to a study on cystic fibrosis transmembrane conductance regulator (CFTR) regulation by ATP and ADP is provided. The data suggest multiple sites are involved in adenosine triphosphate (ATP) regulation of CFTR channels.

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    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Physiology

    Background:

    • The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel.
    • CFTR function is regulated by nucleotide binding domains (NBDs).
    • Adenosine triphosphate (ATP) and adenosine diphosphate (ADP) play key roles in CFTR regulation.

    Purpose of the Study:

    • To correct an error in the presentation of data for Figure 1C in a previous report.
    • To clarify the regulation of CFTR chloride channels by ATP and ADP.
    • To support the interpretation of multiple sites involved in ATP regulation of CFTR.

    Main Methods:

    • Re-plotting of data from Figure 1C with the correct x-axis (P(o) instead of MgATP).
    • Analysis of the corrected data to assess the relationship between nucleotide binding and channel activity.

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  • Comparison of the corrected data with the previously published, incorrect plot.

    • Main Results:

    • The corrected plot for Figure 1C shows data that do not fit a straight line.
    • This non-linear relationship supports the hypothesis of multiple binding sites for ATP in CFTR regulation.
    • The shape of the corrected curve is similar to the erroneous one, explaining the initial oversight.

    Conclusions:

    • The regulation of CFTR by ATP involves more than one site.
    • Accurate data representation is critical for correct scientific interpretation.
    • This correction refines our understanding of CFTR channel gating mechanisms.