Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective disaccharide binding by a macrotetracyclic receptor.

Emmanuel Klein1, Yann Ferrand, Elizabeth K Auty

  • 1School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK BS8 1TS.

Chemical Communications (Cambridge, England)
|September 12, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Free energy simulations on a biomimetic glucose receptor: understanding the selectivity of GluHUT.

Chemical science·2026
Same author

Helical aromatic oligoamide foldamers as selective G-quadruplex ligands.

Nucleic acids research·2025
Same author

Making molecules work - stories of supramolecular translation.

Chemical science·2025
Same author

Bicyclic anionic receptors for carboxylates in water.

Chemical science·2025
Same author

Probing the Nonlinear Chiroptical Activity of Multiturn Aromatic Helices Using Linearly Polarized Light.

Angewandte Chemie (International ed. in English)·2025
Same author

Glucose-sensitive insulin with attenuation of hypoglycaemia.

Nature·2024
Same journal

Bi-modified Ni<sub>3</sub>S<sub>2</sub> promotes selective nitrite-to-hydroxylamine reduction for cyclohexanone oxime synthesis.

Chemical communications (Cambridge, England)·2026
Same journal

Cyclable manganese inventory as a mechanistic descriptor for electrolyte design in rechargeable aqueous Zn-MnO<sub>2</sub> batteries.

Chemical communications (Cambridge, England)·2026
Same journal

Cobalt-iron layered double hydroxides with ligand modification for boosting glycerol electrooxidation-assisted hydrogen production.

Chemical communications (Cambridge, England)·2026
Same journal

Beyond the vacuum: modeling the solid-liquid interface for gas-involving electrocatalysis.

Chemical communications (Cambridge, England)·2026
Same journal

Alkaline-earth carbonate-supported Ru for quinoline hydrogenation: enhanced H<sub>2</sub> activation <i>via</i> electronic metal-support interaction.

Chemical communications (Cambridge, England)·2026
Same journal

Mitigating ionic conductivity limitations <i>in operando</i> electrochemical X-ray photoelectron spectroscopy.

Chemical communications (Cambridge, England)·2026
See all related articles

A novel carbohydrate receptor selectively binds beta-maltosyl disaccharides within its C3-symmetric polar cavity. This system advances molecular recognition, favoring specific sugar structures over previously studied types.

Area of Science:

  • Supramolecular Chemistry
  • Carbohydrate Recognition
  • Host-Guest Chemistry

Background:

  • Designing synthetic receptors for selective carbohydrate binding remains a significant challenge in supramolecular chemistry.
  • Previous carbohydrate receptors often exhibit broad specificity or favor substrates with specific conformational preferences, like 'all-equatorial' arrangements.

Purpose of the Study:

  • To develop a novel carbohydrate receptor with enhanced selectivity for disaccharides.
  • To investigate the binding capabilities of a C3-symmetric receptor with a polar cavity.
  • To explore substrate preference, particularly for beta-maltosyl structures.

Main Methods:

  • Synthesis of a new C3-symmetric molecular host.
  • Binding studies using various disaccharides to determine receptor affinity and selectivity.

Related Experiment Videos

  • Structural analysis to understand the host-guest interactions within the polar cavity.

    • Main Results:

    • The synthesized receptor features a C3-symmetric polar cavity effectively encapsulating disaccharide guests.
    • The receptor demonstrates a clear preference for binding beta-maltosyl disaccharides.
    • This selectivity complements existing systems that favor 'all-equatorial' substrates.

    Conclusions:

    • A novel C3-symmetric receptor has been successfully designed and synthesized.
    • The receptor exhibits high affinity and selectivity for beta-maltosyl disaccharides through encapsulation.
    • This work expands the toolkit for selective carbohydrate recognition and offers a complementary approach to existing methods.